Proteomics Analysis Unravels the Functional Repertoire of Coronavirus Nonstructural Protein 3
نویسندگان
چکیده
منابع مشابه
Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3.
Severe acute respiratory syndrome (SARS) coronavirus infection and growth are dependent on initiating signaling and enzyme actions upon viral entry into the host cell. Proteins packaged during virus assembly may subsequently form the first line of attack and host manipulation upon infection. A complete characterization of virion components is therefore important to understanding the dynamics of...
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UNLABELLED Coronaviruses, the largest RNA viruses, have a complex program of RNA synthesis that entails genome replication and transcription of subgenomic mRNAs. RNA synthesis by the prototype coronavirus mouse hepatitis virus (MHV) is carried out by a replicase-transcriptase composed of 16 nonstructural protein (nsp) subunits. Among these, nsp3 is the largest and the first to be inserted into ...
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110 words Text: 5,202 words 1 AC CE PT ED Copyright © 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Virol. doi:10.1128/JVI.00969-07 JVI Accepts, published online ahead of print on 29 August 2007 on O cber 2, 2017 by gest http/jvi.asm .rg/ D ow nladed fom
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Green fluorescent protein (GFP)-tagged mouse hepatitis coronavirus nonstructural protein 4 (nsp4) was shown to localize to the endoplasmic reticulum (ER) and to be recruited to the coronavirus replicative structures. Fluorescence loss in photobleaching and fluorescence recovery after photobleaching experiments demonstrated that while the membranes of the ER are continuous with those harboring t...
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The coronavirus nucleocapsid protein (N) plays an essential structural role in virions through a network of interactions with positive-strand viral genomic RNA, the envelope membrane protein (M), and other N molecules. Additionally, N protein participates in at least one stage of the complex mechanism of coronavirus RNA synthesis. We previously uncovered an unanticipated interaction between N a...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2008
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.02631-07